Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6094048 | Gastroenterology | 2014 | 11 Pages |
Abstract
In chimeric mice with humanized livers, infection with HBV and HCV appears to activate a natural kill cellâdependent innate immune response. This contributes to the induction and accumulation of aberrant DNA methylation in human hepatocytes.
Keywords
Ras association domain family 1 isoform APCNAMCAMHepatitis B virus XRASSF1AHBxSCIDnatural killerEsr1HCCROSProliferating Cell Nuclear AntigenEpigeneticinterferonIFNGene regulationLiver cancerHBVHepatitis C virusHCVInflammatory responsehepatitis B virusHepatocellular carcinomasevere combined immunodeficientReactive oxygen speciesestrogen receptor 1
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Authors
Yasuyuki Okamoto, Keiko Shinjo, Yasuhiro Shimizu, Tsuyoshi Sano, Kenji Yamao, Wentao Gao, Makiko Fujii, Hirotaka Osada, Yoshitaka Sekido, Shuko Murakami, Yasuhito Tanaka, Takashi Joh, Shinya Sato, Satoru Takahashi, Takaji Wakita, Jingde Zhu,