| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6094158 | Gastroenterology | 2015 | 17 Pages |
Abstract
Chronic stress increases DNA methylation and histone acetylation of genes that regulate visceral pain sensation in the peripheral nervous system of rats. Blocking epigenetic regulatory pathways in specific regions of the spinal cord might be developed to treat patients with chronic abdominal pain.
Keywords
qPCRDRGTRPV1GAPDHVMRMeDIPNR3C1DnmtCRDCNR1GREdorsal root ganglionMethylated DNA immunoprecipitationSmall interfering RNAsiRNAcolorectal distensionEpigenetic modificationchromatin immunoprecipitationpain sensitivityCNScentral nervous systemGlucocorticoid response elementHPAVisceral hyperalgesiahypothalamic-pituitary-adrenalVisceromotor responsequantitative polymerase chain reactiontransient receptor potential vanilloid type 1CHiPCORTCorticosteroneglyceraldehyde-3-phosphate dehydrogenaseCannabinoid receptor 1glucocorticoid receptor
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Authors
Shuangsong Hong, Gen Zheng, John W. Wiley,