| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6094159 | Gastroenterology | 2015 | 20 Pages |
Abstract
Based on experiments in knockout mice and analyses of intestinal tissue samples from patients with IBS-D, MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability. Strategies to block MIR29 might be developed to restore intestinal permeability in patients with IBS-D.
Keywords
mRNATNBSIBS-DIBS-CCLDN1IBS2,4,6-trinitrobenzenesulfonic acidmessenger RNAwater avoidance stressWASGene regulationdiarrhea-predominant irritable bowel syndromeirritable bowel syndromeIntestinal barrier functionMouse modelUTR یا untranslated regions untranslated regionMicroRNAMiRNAwild-typemRNA processingClaudin-1Constipation-predominant irritable bowel syndrome
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
QiQi Zhou, Stefan Costinean, Carlo M. Croce, Alan R. Brasier, Shehzad Merwat, Scott A. Larson, Sarpreet Basra, G. Nicholas Verne,