| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6094164 | Gastroenterology | 2015 | 28 Pages |
Abstract
Thirty-one percent of CRC samples contain alterations in the DATE of the HGF promoter. Disruption of the DATE increased HGF signaling via MET and reduced levels of receptor-interacting serine-threonine kinase 1 and CRC cell necroptosis. DATE alteration might be used as a prognostic factor or to select patients for therapies that target HGFâMET signaling.
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Authors
Danushka Seneviratne, Jihong Ma, Xinping Tan, Yong-Kook Kwon, Eman Muhammad, Mona Melhem, Marie C. DeFrances, Reza Zarnegar,