Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study

Article ID	Journal	Published Year	Pages	File Type
6094318	Gastroenterology	2014	17 Pages	PDF

Abstract

Levels of alkaline phosphatase and bilirubin can predict outcomes (liver transplantation or death) of patients with PBC and might be used as surrogate end points in therapy trials.

Keywords

PBC ULN UDCA Ursodeoxycholic acid autoimmune liver disease Biomarker Upper limit of normal New therapies Primary biliary cirrhosis confidence interval hazard ratio Response to treatment

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study

Authors

Willem J. Lammers, Henk R. van Buuren, Gideon M. Hirschfield, Harry L.A. Janssen, Pietro Invernizzi, Andrew L. Mason, Cyriel Y. Ponsioen, Annarosa Floreani, Christophe Corpechot, Marlyn J. Mayo, Pier M. Battezzati, Albert Parés, Frederik Nevens,