| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6094334 | Gastroenterology | 2014 | 19 Pages |
Abstract
KRAS signaling, via p110α to activate RAC1, is required for transformation in KrasG12D/+;Ptf1a Cre/+ mice.
Keywords
PDADAPIqRT-PCRGAPDHADMpAktGFPmRNAGEFPDK1PBSacinar-to-ductal metaplasiaPI3KPIP3PBDEGFRp21-binding domain4′,6-diamidino-2-phenylindolemessenger RNAPancreatic ductal adenocarcinomasodium dodecyl sulfate/polyacrylamide gel electrophoresisSDS-PAGEOncogeneImmunohistochemistryIHCPancreatic cancerguanine nucleotide exchange factorphospho-Aktphosphatidylinositol-3,4,5-trisphosphatephosphoinositide 3-kinasePhosphate-buffered salinepancreatic intraepithelial neoplasiaSignal transductionPleckstrin Homologyphosphoinositide-dependent kinase 1quantitative reverse-transcription polymerase chain reactionPanINgreen fluorescent proteinCytoskeletonglyceraldehyde-3-phosphate dehydrogenaseEpidermal growth factor receptor
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Authors
Chia-Yen C. Wu, Eileen S. Carpenter, Kenneth K. Takeuchi, Christopher J. Halbrook, Louise V. Peverley, Harold Bien, Jason C. Hall, Kathleen E. DelGiorno, Debjani Pal, Yan Song, Chanjuan Shi, Richard Z. Lin, Howard C. Crawford,