| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6094336 | Gastroenterology | 2014 | 35 Pages |
Abstract
BAs induce pruritus in mice by co-activation of TGR5 and TRPA1. Antagonists of TGR5 and TRPA1, or inhibitors of the signaling mechanism by which TGR5 activates TRPA1, might be developed for treatment of cholestatic pruritus.
Keywords
GPCRTLCAG-protein–coupled receptorNppbGRPPKCAITCDCApKaTRPA1TRPV1mRNADRGTrpDiIPer osmessenger RNADeoxycholic acidTaurolithocholic acidBile acidAllyl isothiocyanateImmunoreactivityItchingsubcutaneousMouse modelSignal transductiontransient receptor potentialtransient receptor potential ankyrin 1Transient receptor potential vanilloid 1protein kinase AProtein kinase Cgastrin-releasing peptideLiverdorsal root ganglia
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Authors
TinaMarie Lieu, Gihan Jayaweera, Peishen Zhao, Daniel P. Poole, Dane Jensen, Megan Grace, Peter McIntyre, Romke Bron, Yvette M. Wilson, Matteus Krappitz, Silke Haerteis, Christoph Korbmacher, Martin S. Steinhoff, Romina Nassini, Serena Materazzi,