| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6094466 | Gastroenterology | 2013 | 11 Pages |
Abstract
In mice, TLR2 signaling regulates intestinal inflammation by controlling ENS structure and neurochemical coding, along with intestinal neuromuscular function. These findings provide information as to how defective TLR2 signaling in the ENS affects inflammatory bowel disease phenotype in humans.
Keywords
GDNFLMMPDNBSENSTLR2nNOSEGCIBDGFAPmRNAmessenger RNAInnate immunityinflammatory bowel diseasesEnteric glial cellsneuronal nitric oxide synthaseenteric nervous systemGlial cell line-derived neurotrophic factorImmune regulationMicrobewild typeGlial fibrillary acidic proteinUlcerative colitisToll-like receptor 2
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Authors
Paola Brun, Maria Cecilia Giron, Marsela Qesari, Andrea Porzionato, Valentina Caputi, Chiara Zoppellaro, Serena Banzato, Alessia Rosaria Grillo, Lisa Spagnol, Raffaele De Caro, Daniela Pizzuti, Vito Barbieri, Antonio Rosato, Giacomo Carlo Sturniolo,