Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6094487 | Gastroenterology | 2013 | 57 Pages |
Abstract
We used single-cell laser capture and high-resolution analysis to show that in human liver HCV infects hepatocytes in nonrandom clusters, whereas expression of antiviral molecules is scattered among hepatocytes. These findings show that quantitative single-cell RNA measurements can be used to estimate the abundance of HCV vRNA per infected human hepatocyte and are consistent with cell-cell propagation of infection in the absence of clustered IFITM3.
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Authors
Abraham J. Kandathil, Frederik Graw, Jeffrey Quinn, Hyon S. Hwang, Michael Torbenson, Alan S. Perelson, Stuart C. Ray, David L. Thomas, Ruy M. Ribeiro, Ashwin Balagopal,