| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6094597 | Gastroenterology | 2014 | 31 Pages |
Abstract
Nanoparticles containing surface CD98 antibody and loaded with siCD98 reduce expression of this protein by colonic epithelial cells and macrophages, and oral administration decreases the severity of colitis in mice. This nanoparticle in hydrogel (chitosan/alginate) formulation might be developed to treat patients with IBD.
Keywords
PEIUACBMDMIBDDSSCD98mRNAbPEIFITCLPSTNF3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromideMPOMTTmessenger RNARNA interferenceSmall interfering RNARNAisiRNAUrocanic acidinterleukinInflammatory bowel diseaseGene silencingdextran sodium sulfatetumor necrosis factorfluorescein isothiocyanatelipopolysaccharideBone marrow–derived macrophageMouse modelmyeloperoxidaseNanoparticlePolyethyleniminepolyethylene glycolBranched polyethyleniminePEG
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Authors
Bo Xiao, Hamed Laroui, Emilie Viennois, Saravanan Ayyadurai, Moiz A. Charania, Yuchen Zhang, Zhan Zhang, Mark T. Baker, Benyue Zhang, Andrew T. Gewirtz, Didier Merlin,