| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6094738 | Gastroenterology | 2014 | 14 Pages |
Abstract
We developed a mouse model of Lynch syndrome (Lgr5-CreERT2;Msh2flox/â mice) and found that environmental factors can modify the number and mutability of the MMR-deficient stem cells. These findings provide evidence that environmental factors can promote development of neoplasias and tumors in patients with Lynch syndrome.
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Gastroenterology
Authors
Kamila Wojciechowicz, Erika Cantelli, Bastiaan Van Gerwen, Mirjam Plug, Anja Van Der Wal, Elly Delzenne-Goette, Ji-Ying Song, Sandra De Vries, Marleen Dekker, Hein Te Riele,