Loss of SMAD4 From Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1+ Myeloid Cells and Facilitate Liver Metastasis

Article ID	Journal	Published Year	Pages	File Type
6094858	Gastroenterology	2013	33 Pages	PDF

Abstract

In human CRC cells, loss of SMAD4 leads to up-regulation of CCL15 expression. Human liver metastases that express CCL15 contain higher numbers CCR1+ cells; patients with these metastases have shorter times of disease-free survival. Reagents designed to block CCL15 recruitment of CCR1+ cells could prevent metastasis of CRC to liver.

Keywords

MMP TGF-β mRNA BMDC DFS TIE SBE messenger RNA Small interfering RNA siRNA disease-free survival transforming growth factor-β Colorectal cancer Colon cancer Bone marrow-derived cell Smad-binding element matrix metalloproteinase BMP Signal transduction bone morphogenetic proteins Carcinoma CRC Chemokine

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Loss of SMAD4 From Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1+ Myeloid Cells and Facilitate Liver Metastasis

Authors

Yoshiro Itatani, Kenji Kawada, Teruaki Fujishita, Fumihiko Kakizaki, Hideyo Hirai, Takuya Matsumoto, Masayoshi Iwamoto, Susumu Inamoto, Etsuro Hatano, Suguru Hasegawa, Taira Maekawa, Shinji Uemoto, Yoshiharu Sakai, Makoto Mark Taketo,