ITF2 Prevents Activation of the β-Catenin-TCF4 Complex in Colon Cancer Cells and Levels Decrease With Tumor Progression

In human colorectal cancer cell lines and tissue samples, ITF2 appears to prevent activation of the β-catenin-TCF4 complex and transcription of its gene targets. Loss of ITF2 promotes the ability of colorectal cancer cells to form xenograft tumors, and is associated with tumor progression and shorter survival times of patients.