| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6095347 | Gastroenterology | 2014 | 22 Pages |
Abstract
eIF5A2 is overexpressed by gene amplification or hypoxia in ESCCs, and associated with up-regulation of HIF1α, metastasis, and shorter survival times of patients. Increased expression of eIF5A2 increases metastasis and angiogenesis in ESCC via the HIF1α-mediated signaling pathway.
Keywords
ESCCqRT-PCRHIF-1OncogeneOxygenchromatin immunoprecipitationImmunofluorescenceImmunohistochemistryIHCGene regulationEMThypoxia-inducible factor-1Vascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)fluorescence in situ hybridizationFishshort hairpin quantitative real-time polymerase chain reactionWestern blottingCHiPEsophageal squamous cell carcinomaepithelial-to-mesenchymal transition
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Authors
Yan Li, Li Fu, Jian-Biao Li, Yanru Qin, Ting-ting Zeng, Jie Zhou, Zhao-Lei Zeng, Jinna Chen, Ting-Ting Cao, Xiaojiao Ban, Chaonan Qian, Zongwei Cai, Dan Xie, Peng Huang, Xin-Yuan Guan,