Article ID Journal Published Year Pages File Type
6095366 Gastroenterology 2014 17 Pages PDF
Abstract
Immunization of KPC mice with Listeria monocytogenes engineered to express KrasG12D, along with depletion of Treg cells, reduces progression of early stage, but not late-stage, PanINs. This approach increases infiltration of the lesion with inflammatory cells. It might be possible to design immunotherapies against premalignant pancreatic lesions to slow or prevent progression to PDA.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
Authors
, , , , , , , , , , , , , ,