| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6095736 | Gastroenterology | 2011 | 15 Pages |
Abstract
Cathelicidin protects against induction of colitis in mice. Increased expression of cathelicidin in monocytes and experimental models of colitis involves activation of TLR9-ERK signaling by bacterial DNA. This pathway might be involved in the pathogenesis of ulcerative colitis.
Keywords
CRAMPCFULL-37RDNADSSTLRDAPIRT-PCRERKIBD4′,6-diamidino-2-phenylindoleRibosomal DNASmall interfering RNAsiRNAterminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labelingEnzyme-linked immunosorbent assayELISATUNELToll-like receptorDextran sulfate sodiumMouse modelsImmune regulationknockoutwild-typecolony-forming unitsreverse-transcription polymerase chain reactionExtracellular signal–regulated kinase
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Authors
Hon Wai Koon, David Q. Shih, Jeremy Chen, Kyriaki Bakirtzi, Tressia C. Hing, Ivy Law, Samantha Ho, Ryan Ichikawa, Dezheng Zhao, Hua Xu, Richard Gallo, Paul Dempsey, Genhong Cheng, Stephan R. Targan, Charalabos Pothoulakis,