| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6095740 | Gastroenterology | 2011 | 14 Pages |
Abstract
Activity-based probes enable noninvasive detection, cellular localization, and proteomic identification of proteases activated during colitis and are potential diagnostic tools for detection of predictive disease biomarkers. Macrophage cathepsins are activated during colitis, and Cat-S activates nociceptors to induce visceral pain via protease-activated receptor-2. Cat-S mediates colitis pain and is a potential therapeutic target.
Keywords
CATDTTDRGVMRTNBSCRDABPcolorectal distensionTrinitrobenzene sulfonic acidinflammationSDS-PAGESodium dodecyl sulfate polyacrylamide gel electrophoresisimmunoreactivity/immunoreactiveParFluorescence tomographyPaindithiothreitolVisceromotor responseActivity-based probeActivity-based probesProteasesCathepsindorsal root gangliaprotease-activated receptorsprotease-activated receptor
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Authors
Fiore Cattaruzza, Victoria Lyo, Ella Jones, David Pham, James Hawkins, Kimberley Kirkwood, Eduardo Valdez-Morales, Charles Ibeakanma, Stephen J. Vanner, Matthew Bogyo, Nigel W. Bunnett,