| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6095757 | Gastroenterology | 2011 | 8 Pages |
Abstract
These observations show that Tfr2 and Hfe are each required for normal signaling of iron status to hepcidin via the Bmp6/Smad1,5,8 pathway. Mice with combined loss of Hfe and Tfr2 up-regulate hepcidin in response to dietary iron loading without increases in liver Bmp6 messenger RNA or steady-state P-Smad1,5,8 levels.
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Authors
Elena Corradini, Molly Rozier, Delphine Meynard, Adam Odhiambo, Herbert Y. Lin, Qi Feng, Mary C. Migas, Robert S. Britton, Jodie L. Babitt, Robert E. Fleming,