| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096018 | Gastroenterology | 2012 | 12 Pages |
Abstract
Muc1, which is up-regulated by Th17 signaling, functions in a negative feedback pathway that prevents an excessive Th17 cell response in inflamed colons of mice. Disruption of this negative feedback pathway, perhaps by variants in Muc1, might contribute to inflammatory bowel disease in patients.
Keywords
T helperRAGMUC1FACSDKOOVAIBDTCrHRPmAbsOvalbumininterferonIFNinterleukinCrohn's diseaseInflammatory bowel diseaseSusceptibilityDendritic cellsRisk factorRecombination Activating Genefluorescence-activated cell sorterMouse modelGenome-wide association studiesGWASImmune regulationMucin 1double knockoutknockoutwild typeMonoclonal antibodiesHorseradish peroxidaseUlcerative colitisT-cell receptor
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Authors
Atsushi Nishida, Cindy W. Lau, Mei Zhang, Akira Andoh, Hai Ning Shi, Emiko Mizoguchi, Atsushi Mizoguchi,