Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of Mice

Article ID	Journal	Published Year	Pages	File Type
6096050	Gastroenterology	2012	13 Pages	PDF

Abstract

Notch1 signaling is required for vascular homeostasis of hepatic sinusoids; it maintains quiescence and differentiation of LSECs in adult mice. Disruption of Notch1 signaling in LSECs leads to spontaneous formation of angiosarcoma, indicating its role as a tumor suppressor in the liver endothelium.

Keywords

HSC PIPC NRH 5-Bromo-2'-deoxyuridine DAPT ECM 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide dll4 LSEC MTT BrdU Vascular tumor Liver cancer liver sinusoidal endothelial cell Hepatic stellate cell Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)endothelial cell medium SEM Scanning electron microscopy knockout wild-type nodular regenerative hyperplasia

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Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of Mice

Authors

Michael T. Dill, Sonja Rothweiler, Valentin Djonov, Ruslan Hlushchuk, Luigi Tornillo, Luigi Terracciano, Silvia Meili-Butz, Freddy Radtke, Markus H. Heim, David Semela,