CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice

Article ID	Journal	Published Year	Pages	File Type
6096064	Gastroenterology	2012	20 Pages	PDF

Abstract

Cerulein induction of pancreatitis in mice involves migration of CD11bhighCD11câGr-1low macrophage from the bone marrow (mediated by CCL2 via CCR2) and suppressor of cytokine signaling 3-dependent activation of macrophage. These findings might lead to new therapeutic strategies for acute pancreatitis.

Keywords

APC signal transducer and activation of transcription RAG-2 nuclear factor−κB MDSC NKT SOCS cKO TCr CDC NF-κB PBS LPS natural killer l-arginine STAT antigen-presenting cell l-Arg interleukin suppressor of cytokine signaling natural killer T cell myeloid-derived suppressor cell Signaling conditional knockout TNF-α lipopolysaccharide Phosphate-buffered saline Mouse model bone marrow wild-type Immune response Chemokine T-cell receptor

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

Preview

CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice

Authors

Keita Saeki, Takanori Kanai, Masaru Nakano, Yuji Nakamura, Naoteru Miyata, Tomohisa Sujino, Yoshiyuki Yamagishi, Hirotoshi Ebinuma, Hiromasa Takaishi, Yuuichi Ono, Kazuyoshi Takeda, Shigenari Hozawa, Akihiko Yoshimura, Toshifumi Hibi,