| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096181 | Gastroenterology | 2013 | 39 Pages |
Abstract
We performed a whole-genome loss-of-function screen to identify genes that mediate the effects of IFNα against human pathogenic viruses. We found that IFNα restricts HCV via actions of general and specific IEGs.
Keywords
DENVmRNAIEGIAVshRNADPP4ISGqRT-PCRPPARIFNARmessenger RNASmall interfering RNAshort hairpin RNAsiRNASTATinterferonIFNGene regulationTreatmentSignal transducer and activator of transcriptionMechanismHepatitis C virusHCVquantitative reverse transcription polymerase chain reactionInfluenza A virusDengue virusvirologyinterferon-stimulated gene
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Authors
Dahlene N. Fusco, Cynthia Brisac, Sinu P. John, Yi-Wen Huang, Christopher R. Chin, Tiao Xie, Hong Zhao, Nikolaus Jilg, Leiliang Zhang, Stephane Chevaliez, Daniel Wambua, Wenyu Lin, Lee Peng, Raymond T. Chung, Abraham L. Brass,