| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096209 | Gastroenterology | 2013 | 20 Pages |
Abstract
The small molecule GS-9620 activates Toll-like receptor 7 signaling in immune cells of chimpanzees to induce clearance of HBV-infected cells. This reagent might be developed for treatment of patients with chronic HBV infection.
Keywords
GGTTLR-7HBV e antigenHBcAgHBV core antigenIP-10ISGHBsAgHBeAgTLRALTPBMCMCPMIPPDCnatural killerγ-glutamyl transpeptidaseAlanine aminotransferaseHBV surface antigenInnate immunityinterferonIFNInterferon-αinterleukinPathogen recognitionToll-like receptorPlasmacytoid dendritic cellperipheral blood mononuclear cellsAntiviralHBVhepatitis B virusmonocyte chemotactic proteinmacrophage inflammatory proteinInterferon-inducible protein 10Interferon-stimulated genes
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Authors
Robert E. Lanford, Bernadette Guerra, Deborah Chavez, Luis Giavedoni, Vida L. Hodara, Kathleen M. Brasky, Abigail Fosdick, Christian R. Frey, Jim Zheng, Grushenka Wolfgang, Randall L. Halcomb, Daniel B. Tumas,