| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096210 | Gastroenterology | 2013 | 15 Pages |
Abstract
In mice, the orphan nuclear receptor Nor-1 activates proliferation of quiescent hepatocytes and is required for hepatocyte proliferation after partial hepatectomy. Nor-1 and its gene targets are also up-regulated in human HCC samples. Nor-1 activates a transcriptional program that induces hepatocyte proliferation independently of inflammatory signaling pathways.
Keywords
PCNACCND1VCAM-1Cyclin D1CCNE1Cyclin E1STAT 3shRNAmRNAHCCmessenger RNAsmall hairpin RNAProliferating Cell Nuclear AntigeninterleukinLiver regenerationLiver growthSurgerysignal transducer and activator of transcription 3MetabolismVascular cell adhesion molecule 1Nor-1Partial hepatectomyHepatocellular carcinomaNuclear receptornuclear receptors
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Authors
Michele Vacca, Stefania Murzilli, Lorena Salvatore, Giuseppe Di Tullio, Andria D'Orazio, Giuseppe Lo Sasso, Giusi Graziano, Massimo Pinzani, Marcello Chieppa, Renato Mariani-Costantini, Giuseppe Palasciano, Antonio Moschetta,