| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096342 | Gastroenterology | 2010 | 10 Pages |
Abstract
A bisulfite-pyrosequencing assay to measure methylation of the IGF2 DMR0 is robust and applicable to paraffin-embedded tissue. IGF2 DMR0 hypomethylation in colorectal tumor samples is associated with shorter survival time, so it might be developed as a prognostic biomarker.
Keywords
CIMPIGF2MSIDMRCpG island methylator phenotypeLoss of imprintingstandard deviationEpigeneticsMicrosatellite instabilityconfidence intervalinsulin-like growth factor 2LOIDifferentially methylated regionClinical outcomehazard ratioTherapeutic targetpolymerase chain reactionPCRSingle nucleotide polymorphismquartileSNPImprinting Control Region
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Authors
Yoshifumi Baba, Katsuhiko Nosho, Kaori Shima, Curtis Huttenhower, Noriko Tanaka, Aditi Hazra, Edward L. Giovannucci, Charles S. Fuchs, Shuji Ogino,