| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096393 | Gastroenterology | 2010 | 16 Pages |
Abstract
CD166 is highly expressed within the endogenous intestinal stem cell niche. CD166-positive cells appear at multiple stages of intestinal carcinoma progression, including benign and metastatic tumors. Further studies should investigate the function of CD166 in stem cells and the stem cell niche, which might have implications for normal intestinal homeostasis. CD166 has potential as a therapeutic target for CRC.
Keywords
ESAMsi-1Cy3qRT-PCRFACSCSCcDNAComplementary DNAEDTAEthylenediaminetetraacetic acidfluorescent-activated cell sortingSmall intestineembryonic dayColorectal cancerColon cancerintestinal stem cellscancer stem cellMusashi-1ALCAMactivated leukocyte cell adhesion moleculeQuantitative reverse-transcriptase polymerase chain reactionCRC
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Authors
Trevor G. Levin, Anne E. Powell, Paige S. Davies, Alain D. Silk, Adria D. Dismuke, Eric C. Anderson, John R. Swain, Melissa H. Wong,