Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

Article ID	Journal	Published Year	Pages	File Type
6096400	Gastroenterology	2010	9 Pages	PDF

Abstract

These results imply a role for PHD1 as a positive regulator of intestinal epithelial cell apoptosis in the inflamed colon. Genetic loss of PHD1 is protective against colitis through decreased epithelial cell apoptosis and consequent enhancement of intestinal epithelial barrier function. Thus, targeted PHD1 inhibition may represent a new therapeutic approach in IBD.

Keywords

PBS DMOG PHD HIF TEER IL-1β FITC DSS short interfering RNA siRNA Colitis interleukin-1 β terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling TUNEL Apoptosis dextran sulphate sodium Hypoxia Inducible Factor fluorescein isothiocyanate Phosphate-buffered saline transepithelial electrical resistance hydroxylase Hypoxia Prolyl hydroxylase

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

Authors

Murtaza M. Tambuwala, Eoin P. Cummins, Colin R. Lenihan, Judit Kiss, Markus Stauch, Carsten C. Scholz, Peter Fraisl, Felix Lasitschka, Martin Mollenhauer, Sean P. Saunders, Patrick H. Maxwell, Peter Carmeliet, Padraic G. Fallon, Martin Schneider,