Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6096567 | Gastroenterology | 2010 | 16 Pages |
Abstract
We developed a rat model of narcotic bowel-like syndrome and showed that spinal microglia activation mediates the development of morphine-induced visceral hyperalgesia; peripheral neuroimmune activation and spinal dynorphin release represent an important mechanism in the delayed and long-lasting morphine-induced colonic hypersensitivity response to CRD.
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Authors
Simona Agostini, Helene Eutamene, Christel Cartier, Maria Broccardo, Giovanna Improta, Eric Houdeau, Carla Petrella, Laurent Ferrier, Vassillia Theodorou, Lionel Bueno,