| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096574 | Gastroenterology | 2010 | 12 Pages |
Abstract
SIGIRR acts as a tumor suppressor in the colon by inhibiting TLR-induced, mTOR-mediated cell-cycle progression and genetic instability.
Keywords
NF-κBSIGIRR4EBPnuclear factor−κB4E binding proteinCyclin D1IL-1RGSK3βTLRAPCmTORLPSSTAT3c-Mycadenomatous polyposis coliloss of heterozygosityinterleukinToll-like receptorLOHlipopolysaccharideSignal transducers and activators of transcription 3mammalian target of rapamycinGlycogen synthase kinase 3βinterleukin-1 receptor
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Authors
Hui Xiao, Weiguo Yin, Mohammed A. Khan, Muhammet F. Gulen, Hang Zhou, Ho Pan Sham, Kevan Jacobson, Bruce A. Vallance, Xiaoxia Li,