| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096581 | Gastroenterology | 2010 | 11 Pages |
Abstract
This study shows that triptolide kills pancreatic cancer cells by 2 different pathways. It induces caspase-dependent apoptotic death in MiaPaCa-2, Capan-1, and BxPC-3, and induces caspase-independent autophagic death in metastatic cell lines S2-013, S2-VP10, and Hs766T, thereby making it an attractive chemotherapeutic agent against a broad spectrum of pancreatic cancers.
Keywords
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Authors
Nameeta Mujumdar, Tiffany N. Mackenzie, Vikas Dudeja, Rohit Chugh, Mara B. Antonoff, Daniel Borja-Cacho, Veena Sangwan, Rajinder Dawra, Selwyn M. Vickers, Ashok K. Saluja,