| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6096782 | Gastroenterology | 2011 | 10 Pages |
Abstract
Class I and II HLA genotypes affect susceptibility to AC-DILI, indicating the importance of the adaptive immune response in pathogenesis. The HLA genotypes identified will be useful in studies of the pathogenesis of AC-DILI but have limited utility as predictive or diagnostic biomarkers because of the low positive predictive values.
Keywords
ULNPBCALTCIOMSADMEASTAspartate aminotransferaseDrug-induced liver injuryalanine transaminaseALPAlkaline phosphataseAmoxicillin-clavulanatenegative predictive valueUpper limit of normalDILIDILINHepatotoxicityPrimary biliary cirrhosisDrug-Induced Liver Injury NetworkLinkage disequilibriumPharmacogenomicsconfidence intervalmajor histocompatibility complexMHCGenome-wide association studyGWASNPV یا negative predictive valueodds ratioSingle nucleotide polymorphismSNP
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Authors
M. Isabel Lucena, Mariam Molokhia, Yufeng Shen, Thomas J. Urban, Guruprasad P. Aithal, Raúl J. Andrade, Christopher P. Day, Francisco Ruiz-Cabello, Peter T. Donaldson, Camilla Stephens, Munir Pirmohamed, Manuel Romero-Gomez, Jose Maria Navarro,