| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6108022 | Journal of Hepatology | 2009 | 11 Pages |
Abstract
NS5A and core proteins induce oxidative stress-mediated Ca2+ homeostasis alterations in human hepatocyte-derived cells, which might underlie the effects of both proteins in the pathogenesis of liver disorders associated to HCV infection.
Keywords
SOCEIFN-alphaActin reorganizationsarcoendoplasmic reticulum Ca2+-ATPaseNS5A proteinHBSThapsigarginPMCAChlDCFH-DA2′,7′-dichlorodihydrofluorescein diacetateHEPES-buffered salineROS/RNSChang liver cellsCalcium signallingendoplasmic reticulumPlasma membrane Ca2+-ATPaseSERCAHCVHepatitis C virusStore-operated calcium entryCore proteinQuercetinReactive oxygen and nitrogen species
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Authors
Natalia Dionisio, Maria V. Garcia-Mediavilla, Sonia Sanchez-Campos, Pedro L. Majano, Ignacio Benedicto, Juan A. Rosado, Gines M. Salido, Javier Gonzalez-Gallego,