| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6108205 | Journal of Hepatology | 2008 | 11 Pages |
Abstract
HCV-specific IL-10 Tr1 responses may play a dual role in HCV infection, dampening effector T-cells to promote viral persistence in acute infection but also protecting against progressive fibrosis in chronic infection.
Keywords
PBMCSpot-forming unitSFUpegylated interferon-alphaPEG-IFNαTr1Th2Th1TregIL-10PHAPhytohemagglutininSVRCD8+ T-cellsregulatory T-cellsstandard deviationinterferonIFNinterferon-gammaInterleukin-10SODperipheral blood mononuclear cellsSuperoxide dismutaseHepatitis CHCVHepatitis C virusReverse-transcriptase polymerase chain reactionPCRSustained virologic response
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Authors
David E. Kaplan, Fusao Ikeda, Yun Li, Nobuhiro Nakamoto, Sutharsan Ganesan, Mary E. Valiga, Frederick A. Nunes, K. Rajender Reddy, Kyong-Mi Chang,