Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6108472 | Journal of Hepatology | 2008 | 12 Pages |
Abstract
This study suggests that Ang II causes development and progression of NAFLD in the transgenic Ren2 rat model by increasing hepatic ROS. Our findings also support a potential role of RAS in prevention and treatment of NAFLD.
Keywords
NAFLDAT1R4-HNEALTRASNADPHACE4-hydroxy-2-nonenalROSAlanine aminotransferaseAngiotensin-converting enzymeAngiotensin IIangiotensin type 1 receptorNon-alcoholic steatohepatitisnon-alcoholic fatty liver diseaseTriglyceridesOxidative stressTUNELAng IISODSuperoxide dismutaseRenin–angiotensin systemSprague–Dawley ratNash nicotinamide adenine dinucleotide phosphateC-reactive proteinCRPReactive oxygen species
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Authors
Yongzhong Wei, Suzanne E. Clark, E. Matthew Morris, John P. Thyfault, Grace M.E. Uptergrove, Adam T. Whaley-Connell, Carlos M. Ferrario, James R. Sowers, Jamal A. Ibdah,