| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6108840 | Journal of Hepatology | 2009 | 10 Pages |
Abstract
FGFR4 contributes significantly to HCC progression by modulating AFP secretion, proliferation and anti-apoptosis. Its frequent overexpression in patients renders its inhibition a novel and much needed pharmacological approach against HCC.
Keywords
GAPDHTKIsFRS2αFGF19FGFR4FGFRHCCMTTsiRNAalpha-fetoproteinsmall interfering ribonucleic acidanalysis of varianceANOVAProliferationAFPELISAEnzyme-linked immunosorbent assayTyrosine kinaseApoptosisfibroblast growth factor 19Tyrosine kinase inhibitorsHBVHepatitis C virusHCVhepatitis B virusSingle nucleotide polymorphismSNPHepatocellular carcinomaglyceraldehyde 3-phosphate dehydrogenasefibroblast growth factor receptor
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Authors
Han Kiat Ho, Sharon Pok, Sylvia Streit, Jens E. Ruhe, Stefan Hart, Kah Suan Lim, Hooi Linn Loo, Myat Oo Aung, Seng Gee Lim, Axel Ullrich,