| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6108846 | Journal of Hepatology | 2009 | 8 Pages |
Abstract
In this cohort of PSC patients, several CFTR-variants affecting the functional properties of the CFTR protein seem to offer protection against the development of PSC, confirming our hypothesis that CFTR might be implicated in the pathogenesis of PSC.
Keywords
CFTRIBDPSCCCAFDRDNAdesoxyribonucleic acidbiliary tract diseasesCrohn’s diseaseInflammatory bowel diseaseDisease susceptibilitycystic fibrosis transmembrane conductance regulatorLinkage disequilibriumCystic fibrosisfalse discovery rateodds ratiopolymerase chain reactionPCRMembrane proteinsGeneticsPrimary sclerosing cholangitisCholangiocarcinomaUlcerative colitisIndeterminate colitispattern recognition receptors
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Liesbet Henckaerts, Martine Jaspers, Werner Van Steenbergen, Liesbet Vliegen, Johan Fevery, Hilde Nuytten, Tania Roskams, Paul Rutgeerts, Jean-Jacques Cassiman, Séverine Vermeire, Harry Cuppens,