| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6109150 | Journal of Hepatology | 2008 | 8 Pages |
Abstract
These data point to a primary role of genes encoding regulators of the immune system in the susceptibility to PBC. They also demonstrate that allelic variations in TNFα and SLC4A2/AE2 have a significant impact on the evolutive profile of PBC under UDCA therapy.
Keywords
TNFαFIC1Tumor necrosis factor α (TNFα)CTLA-4Ursodeoxycholic acid (UDCA)LXRαPrimary biliary cirrhosis (PBC)PXRNtcpUDCAMDR1FXRAE2BSEPMDR3PBCCFTRfarnesoid X receptorcytotoxic T-lymphocyte antigen 4Ursodeoxycholic acidtumor necrosis factor αcystic fibrosis transmembrane conductance regulatorPrimary biliary cirrhosisanion exchanger 2multidrug resistance 1Single nucleotide polymorphismBile salt export pumpSNPliver X receptor αPregnane X receptor
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Authors
Raoul Poupon, Chen Ping, Yves Chrétien, Christophe Corpechot, Olivier Chazouillères, Tabassome Simon, Simon C. Heath, Fumihiko Matsuda, Renée E. Poupon, Chantal Housset, Véronique Barbu,