| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6109691 | Journal of Hepatology | 2009 | 12 Pages |
Abstract
This study suggests that AdshPAI treatment has a protective effect on hepatocytes and ameliorates liver fibrogenesis. Inhibiting the upregulation of PAI-1 during liver fibrosis may be an antifibrotic pathway worth exploiting.
Keywords
BDLdimethylnitrosamineHSCsuPAPAI-1RNA interferingDMNtPAMmpsECMSmall interfering RNARNAisiRNAAdenovirusterminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelingRNA interference (RNAi)TUNELHepatic stellate cellsTissue-type plasminogen activatorurokinase type plasminogen activatorHepatic fibrosisExtracellular matrixMatrix metalloproteinasesPlasminogen activator inhibitor-1plaque forming unitpfuplasminogen activator inhibitor-1 (PAI-1)bile duct ligation
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Authors
Ping-Fang Hu, Han Chen, Wei Zhong, Yong Lin, Xin Zhang, Yue-Xiang Chen, Wei-Fen Xie,