Lipopolysaccharide triggered TNF-Î±-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model

Article ID	Journal	Published Year	Pages	File Type
6109707	Journal of Hepatology	2009	8 Pages	PDF

Abstract

LPS up-regulated TNF-Î± production, which induced hepatocyte apoptosis in a murine NASH model. LPS may play a key role in the pathogenesis of NASH.

Keywords

N-acetyl-l-cysteine NAFLD terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling TNF ASK1 MCD PTX TBARS NAC α-SMA Jnk c-Jun N-terminal kinase ROS Hydrogen peroxide Non-alcoholic steatohepatitis alcoholic steatohepatitis α-smooth muscle actin non-alcoholic fatty liver disease Oxidative stress tumour necrosis factor-α TUNEL Ash Apoptosis tumor necrosis factor Fibrosis lipopolysaccharide thiobarbituric acid-reactive substances Nash H2O2 Pentoxifylline apoptosis signal-regulating kinase 1 Reactive oxygen species

Related Topics

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Lipopolysaccharide triggered TNF-Î±-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model

Authors

Hiroshi Kudo, Terumi Takahara, Yutaka Yata, Kengo Kawai, Wei Zhang, Toshiro Sugiyama,