| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6109895 | Journal of Hepatology | 2009 | 12 Pages |
Abstract
The preventive effect of PGZ on MCD-induced steatohepatitis depends on adiponectin upregulation but apparently does not involve AMPK or PPARα activation. The inhibition of SREBP-1c and dependent repression of lipogenesis are likely to participate in this effect. The mechanisms by which PGZ and adiponectin control SREBP-1c and inflammation remain to be elucidated.
Keywords
NF-κBAdipoHSP-90AdipoRIκBαMCDACOmTORFASAMPKACCacyl CoA oxidaseAMP-activated protein kinasecDNAadiponectinNon-alcoholic steatohepatitisacetyl-CoA carboxylasecomplementary deoxyribonucleic acidFatty acidfatty acid synthaseNuclear factor-kappa Bmethionine and choline deficientNash mammalian target of rapamycinHeat shock protein 90adiponectin receptor
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Authors
Alain Da Silva Morais, Valérie Lebrun, Jorge Abarca-Quinones, Sonia Brichard, Louis Hue, Bruno Guigas, Benoit Viollet, Isabelle A. Leclercq,