| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6110029 | Journal of Hepatology | 2008 | 10 Pages |
Abstract
We show that caffeine strongly down-modulates TGF-β-induced CTGF expression in hepatocytes by stimulation of degradation of the TGF-β effector SMAD 2, inhibition of SMAD3 phosphorylation and up-regulation of the PPARγ-receptor. Long-term caffeinization might be an option for anti-fibrotic trials in chronic liver diseases.
Keywords
CREBCREcAMP-specific phosphodiesteraseRT-PCRNIDDKPPARγcAMP-PDENHANESPhospho-SmadCBP8-br-cAMPcAMPCyclic adenosine monophosphateSmurfrecombinant humanNational Health and Nutrition Examination SurveyConnective tissue growth factorReverse-transcriptase polymerase chain reactionCREB binding proteincAMP response element binding proteinControlperoxisome proliferator-activated receptor γ
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Olav A. Gressner, Birgit Lahme, Katharina Rehbein, Monika Siluschek, Ralf Weiskirchen, Axel M. Gressner,