Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6113512 | Critical Reviews in Oncology/Hematology | 2016 | 29 Pages |
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side-effect without any FDA-approved treatment option. Prior reviews focus mostly on pharmacological interventions, but nonpharmaceutical interventions have also been evaluated. A Web of Science and PubMed database search to identify relevant RCTs from January 2005 to May 2015 included the terms: CIPN, cancer; and supplements, vitamin E, goshajinkigan, kampo, acetyl-l-carnitine, carnitine, alpha-lipoic acid, omega-3, glutamine, or glutamate; or massage, acupuncture, mind-body practice, yoga, meditation, Tai-Chi, physical activity, or exercise. Of 1465 publications screened, 12 RCTs evaluated natural products and one evaluated electroacupuncture. Vitamin E may help prevent CIPN. l-Glutamine, goshajinkigan, and omega-3 are also promising. Acetyl-l-carnitine may worsen CIPN and alpha-lipoic acid activity is unknown. Electroacupuncture was not superior to placebo. No RCTs were published regarding other complementary therapies, although some studies mention positive incidental findings. Natural products and complementary therapies deserve further investigation, given the lack of effective CIPN interventions.
Keywords
CIPNNCI-CTCAEGoshajinkiganFGSCPNOPNNSSNDSALANCVEPABMCAlcFACITacetyl-l-carnitinealpha-lipoic acidEicosapentaenoic aciddocosahexaenoic acidOmega-3 fatty acidsDHAnerve conduction velocitychemotherapy-induced peripheral neuropathyNational Cancer Institute Common Terminology Criteria for Adverse EventsPPNhuman immunodeficiency virusHIV
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Authors
Cloé Brami, Ting Bao, Gary Deng,