Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6113647 | Critical Reviews in Oncology/Hematology | 2014 | 15 Pages |
Abstract
Brain tumors are still the leading cause of cancer morbidity and mortality among children, despite different therapeutic options including neurosurgery, chemotherapy and radiation. As angiogenesis is highly crucial in brain tumor growth and progression, numerous clinical trials evaluating diverse anti-angiogenic agents have been described. In the present review, we aimed to answer the question if anti-angiogenic therapy is an effective strategy in the treatment of children with brain tumors. Although some encouraging results have been published of anti-angiogenic therapy targeting vascular endothelial growth factor (VEGF)/VEGF receptor signaling or epidermal growth factor receptor (EGFR), still more insight is warranted to be highly conclusive about the efficacy of anti-angiogenic therapy with currently potential upcoming anti-angiogenic agents in pediatric brain tumors. However, given the need for new therapeutic strategies, multi targeted therapy with anti-angiogenic agents anticipating on possible tumor escape mechanisms could be effective in the future treatment of pediatric brain tumors.
Keywords
HIFBrain stem gliomaTZMColony stimulating factor 1 receptorfibroblast growth factor (receptor)PDGF(R)CSF-1RVEGF(R)PRESEGF(R)LGGHGGRetrospectiveDIPGinfbFGFCPMMMPBSGDllIgf1Clinical trialspilocytic astrocytomaALKangiopoietinAngiogenesisFLAIRMRIHCGAnginterleukinfluid-attenuated inversion recoveryMagnetic resonance imagingTemozolomidetumor necrosis factor αPediatric brain tumorsPositron emission tomographyAnti-angiogenic therapyRadiotherapyRONPosterior reversible encephalopathy syndromeCyclophosphamideChemotherapyProSepidermal growth factor (receptor)placental growth factorvascular endothelial growth factor (receptor)basic fibroblast growth factorinsulin-like growth factor 1Hypoxia Inducible FactorTNF-αAnaplastic lymphoma kinasematrix metalloproteinasePETProspectiveCase reportHigh-grade gliomaLow-grade gliomadiffuse intrinsic pontine gliomaEpidermal growth factor receptorretro
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Authors
Mariska Sie, Wilfred F.A. den Dunnen, Eelco W. Hoving, Eveline S.J.M. de Bont,