Pre infusion, post thaw CD34+ peripheral blood stem cell enumeration as a predictor of haematopoietic engraftment in autologous haematopoietic cell transplantation

A significant loss of viable CD34+ cells occurs during processing, cryopreservation and thawing. Low numbers of viable CD34+ cells infused post thaw will still result in adequate neutrophil engraftment however may delay platelet engraftment. Low viable CD34+ cell numbers have significant effects on admission duration and use of haematopoietic supportive measures with consequent effects on healthcare resources.