Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6114126 | Transfusion and Apheresis Science | 2014 | 11 Pages |
Abstract
Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9Â g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.
Keywords
TRICCRRTSIRSrecHCTRBCDMECCRFQALYsNHSAKIRCTSAERandomised controlled trialacute kidney injuryMyocardial infarctionICUTransfusionCardiac surgeryCABGNational Health ServiceNICErenal replacement therapyQuality Adjusted Life YearsRed cellSystemic inflammatory response syndromeadverse eventSerious adverse eventcase report formNational Institute for Health and Care ExcellenceRestrictivehaematocrithaemoglobinintensive care unitsUnited KingdomProtocolGeneral practitionerCoronary artery bypass graftResearch Ethics Committeered blood cell
Related Topics
Health Sciences
Medicine and Dentistry
Hematology
Authors
Rachel C.M. Brierley, Katie Pike, Alice Miles, Sarah Wordsworth, Elizabeth A. Stokes, Andrew D. Mumford, Alan Cohen, Gianni D. Angelini, Gavin J. Murphy, Chris A. Rogers, Barnaby C. Reeves,