Inherited anomalies of innate immune receptors in pediatric-onset inflammatory diseases

Article ID	Journal	Published Year	Pages	File Type
6114416	Autoimmunity Reviews	2015	7 Pages	PDF

Abstract

Pattern-recognition receptors (PRRs) can detect various pathogen-associated molecular patterns such as carbohydrates, nucleic acids or bacterial peptides and play a major role in both innate and adaptive immunity. In physiological conditions, the engagement of PRRs triggers the production of proinflammatory cytokines and promotes pathogen destruction. Inappropriate stimulation or defective regulation of PRR has been recently evidenced in several inherited inflammatory disorders. This new field of childhood-onset inflammatory diseases encompass the so-called type-I interferon-related diseases and autoinflammatory diseases.

Keywords

CARD9 ALRs nucleotide-binding oligomerization domain containing 2 TIRAP IFI16 TRAF3 AIM2 RLR MAVS FCL MDA5 SAMHD1 NOD2 RIG-I ADAR1 TBK1 IRF TREX1 TNF receptor-associated factor 3 Toll-interleukin 1 receptor (TIR) domain containing adaptor protein Interleukin-1 receptor-associated kinase 4 NLR family pyrin domain containing 3 Acp5 UNC93B1 IFIH1 Systemic-onset juvenile idiopathic arthritis ISRE NLRC3 SAVI JMP cyclic GMP-AMP synthase NLRs IRAK4 CLRs TNFα IKK TRAP CAPS AGS PAMPs DAI ASC PID MYD88 Cgas PRRs FMF NLRP3 SoJIA HSV-1 IFNAR IκB kinase MAPK Stat1 TLRs TRIF Tartrate resistant acid phosphatase pathogen-associated molecular patterns Autoimmune diseases autoinflammatory diseases Familial Mediterranean fever Traps tumor necrosis factor α TANK-binding kinase 1 Aicardi-Goutières syndrome PFAPA syndrome Cryopyrin-associated periodic syndrome Cytokines CANDLE IFN regulatory factor LUBAC systemic lupus erythematous SLE signal transducer and activator of transcription 1 STING absent in melanoma 2 mitochondrial antiviral signaling protein Melanoma Differentiation-Associated protein 5 apoptosis-associated speck-like protein containing a CARD mitogen-activated protein kinase SMS JAK retinoic acid-inducible gene 1 Genetics primary immunodeficiency Children NOD-like receptors pattern recognition receptors pathogen recognition receptors Toll-like receptors