| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6114524 | Autoimmunity Reviews | 2014 | 5 Pages |
Abstract
Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Osnat Jarchowsky Dolberg, Yair Levy,