Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6114559 | Autoimmunity Reviews | 2014 | 6 Pages |
Abstract
Autoantibodies to PLA2R1 may not only play a role in the development of primary MN, but also serve as a marker for diagnosis, disease activity and therapy monitoring. Antibody detection is crucial to discriminate between patients with primary MN and those with a secondary form of the disease, as both forms require different diagnostic approaches and treatment strategies. Standardized test systems based on recombinant PLA2R1 allow for the sensitive and specific analysis of anti-PLA2R1 autoantibodies. Further research into pathogenic mechanisms and other disease markers can pave the way for improved patient care.
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Authors
Wolfgang Schlumberger, Nora Hornig, Sascha Lange, Christian Probst, Lars Komorowski, Kai Fechner, Cornelia Dähnrich, Winfried Stöcker,