p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris

Article ID	Journal	Published Year	Pages	File Type
6114595	Autoimmunity Reviews	2013	11 Pages	PDF

Abstract

âº p38 MAPK is a regulator of innate and adaptive self-targeting immunity. âº Inhibition of p38 MAPK abrogates self-destruction in various autoimmune diseases. âº The effectiveness of pharmaceutic p38 inhibitors has been questioned. âº p38 MAPK participates in ANCA-mediated activation of human neutrophils. âº Pemphigus is an ideal model to study p38 MAPK-mediated humoral autoimmunity.

Keywords

ANCA TNF MAPK phosphatase-1 T-reg MAPKK Th1 TTP AIH Gadd45 TGF TLR EAE Hsp DSG LPS TCr DUSP MAPK MAPK kinase MAPK kinase kinase pemphigus foliaceus T-helper 1 Rheumatoid arthritis anti-neutrophil cytoplasmic antibody experimental autoimmune encephalomyelitis Autoantibody interferon IFN interleukin Autoimmune disease Toll-like receptor dual specificity phosphatase autoimmunity desmoglein Signaling tumor growth factor tumor necrosis factor Germinal center Autoimmune hepatitis Heat shock protein mitogen activated protein kinase pemphigus vulgaris T-cell receptor