| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6114600 | Autoimmunity Reviews | 2013 | 12 Pages |
Abstract
Systemic Lupus Erythematosus (SLE) is a clinically diverse, chronic autoimmune disease with inflammation in several organ systems. Its pathogenesis is complex, but includes many factors that can be influenced by glucocorticoids (GCs). Indeed, GCs constitute the corner-stone in SLE-treatment. However, guidelines for GC-treatment of the different disease manifestations are lacking and not every patient responds (sufficiently). The focus of this systematic review is to evaluate the differential glucocorticoid treatment of various SLE manifestations. In addition, some relevant mechanisms of glucocorticoid action as well as resistance are discussed.
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Authors
Remco K.M.A.C. Luijten, Ruth D. Fritsch-Stork, Johannes W.J. Bijlsma, Ronald H.W.M. Derksen,